CASE STUDY: Scientific expertise to solve technical roadblocks

Situation:

A client was developing a new apheresis device.  Monitoring complement activation after blood exposure, they found higher levels compared to historical experience.  The client was concerned this would slow development of the device.

BioPhia Role:

BioPhia was engaged to provide SME review of the in vitro complement activation data and provide insight into possible reasons for the apparent levels and suggest the next steps.

Action:

An initial meeting produced a document that explained the data in the context of extracorporeal blood contact and outlined a set of follow-up experiments to resolve any issues.

Result:

A white paper was generated that included background on complement activation, the original data and results from follow-up work.  This was included as an addendum to an internal report on the device development project.